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"Halogen bonding enough is surely an emerging noncovalent interaction for constructing supramolecular assemblies. Although just like the much more familiar hydrogen bonding, 4 key differences amongst these two interactions make halogen bonding a unique instrument for molecular recognition and the design and style of practical components. Initially, halogen bonds are usually way more directional than (single) hydrogen bonds. 2nd, the interaction strength scales with all the polarizability of your bond-donor atom, a feature that researchers can tune as a result of single-atom mutation. Additionally, halogen bonds are hydrophobic whereas hydrogen bonds are hydrophilic. Lastly, the dimension with the bond-donor atom (halogen) is appreciably more substantial than hydrogen.
As a result, halogen bonding supplies supramolecular chemists with design and style tools that cannot be quickly met with other styles of noncovalent interactions and opens up unprecedented possibilities inside the design of clever practical elements.
This Account highlights the latest advances from the design and style of halogen-bond-based practical elements. Each on the exclusive options of halogen bonding, directionality, tunable interaction power, hydrophobicity, and substantial donor atom dimension, makes a big difference. Taking advantage of the hydrophobicity, researchers have intended small-size ionunder transporters. The massive halogen atom dimension presented a platform for constructing all-organic light-emitting crystals that effectively make triplet electrons and have a substantial phosphorescence quantum yield.
The tunable interaction strengths present resources for comprehending light-induced macroscopic motions in photoresponsive azobenzene-containing polymers, and the directionality renders halogen bonding helpful inside the style and design on functional supramolecular liquid crystals and gel-phase products. Though halogen bond based mostly practical elements layout continues to be in its infancy, we foresee a vivid potential for this area. We expect that supplies created based on halogen bonding could result in applications in biomimetics, optics/photonics, practical surfaces, Interleukin-6 receptor and photoswitchable supramolecules."