So, Who Really Needs A GDC-0941?

A platform Selumetinib (AZD6244) that incorporates computational library design, parallel solution-phase synthesis, constant movement hydrogenation, and automated higher throughput purification and reformatting technologies was applied for the manufacturing of a 120-member library of 1-aryl-4-amino-piperidine analogues for drug discovery screening. The application described herein demonstrates the advantages of computational library style coupled that has a flexible, modular approach to library synthesis. The enabling technologies described could be readily adopted from the standard medicinal chemist without having intensive coaching andselleck inhibitor lengthy system advancement occasions.