The low solubility of ozone in aqueous media has

In all possible applications, the Progesterone density (ED) of the targeted molecules plays an important role on the electrophilic attack of ozone. As a general feature, increasing ED accounts for increasing reactivity toward ozone.
This dependence may be significantly influenced by the presence of a catalyst [7]. For phenolic compounds, for instance, the reactivity toward ozone is strongly dependent on the number, type and position of functional groups attached to the aromatic ring.