There is no monthly fee at all associated with Guild Wars 2, keeping up the tradition of the Guild Wars business model. Mike O'Brien has stated that expansions and/or mini-expansions are more likely than standalone campaigns, but a final decision has not been made yet. The game is on multiple servers or "worlds," but players will not be bound to a world/server. They can visit other servers at any time using guest mode (Guest mode will not be available at launch but will be added later), but will not be able to participate in PvP on behalf of the server they are visiting. They can permanently change servers easily by paying a fee of 1800 gems, which are purchased through the cash store, but there is a restriction of changing servers once every seven days. Guild Wars 2 is designed to run on a wide range of computer specifications, but has higher requirements than the original Guild Wars.

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The original Guild Wars continues to be supported after the release of Guild Wars 2. This includes continued holiday events and tournaments.

The control & movement system is going to be significantly changed. In particular, mouse movement in the form has been removed from the game; however, target locking will still function. Control of combat is more active; including blocking skills that are "held down", ground-targeting for spells and attacks, and hit detection that allows one player to block area-based damage from reaching other players. Guild Wars 2 is a true 3D environment which allows characters to jump over obstacles as well as swim and dive underwater. New animation coding allow separates tracks for upper and lower body components, allowing players to activate more skills while running or jumping for smoother combat immersion.

Flight is not to be a featured character capability in Guild Wars 2.
Game engine

Guild Wars 2 uses a heavily modified Guild Wars game engine which includes support for true 3D environments, more detailed environments and models, better lighting and shadows, new animation and effects systems, plus new audio and cinematics engines and a more flexible combat and skill-casting system.

Gaile Gray has indicated the game supports DirectX 10, but does not require it to play. Guild Wars 2 utilises the Havok physics engine to provide ragdoll animation and destructible environments, as well as occlusion culling technology licensed from Umbra Software to optimise 3D object rendering.
Underwater exploration