Particle size distributions before and after functionalization

Quercetin is a common secondary plant metabolite possessing a variety of therapeutic medicinal uses. It has been shown to reduce the effects of oxidative stress on a variety of cell lines by scavenging free radical oxygen species [1] and [2]. Quercetin has been investigated for disease prevention, for example its roles in modulating signal transduction pathways associated with carcinogenesis as well as Alzheimer\'s disease [3] and [4]. The anti-thrombosis and anti-inflammatory effects of quercetin may aid in the AS 1949490 of obesity [5]. Secondary metabolites produced by plants, such as quercetin, are of high value, although traditional methods of metabolite recovery are expensive, detrimental to plant cells and require large quantities of plant cell tissue [6]. A common method of recovery is exudation, or altering of the cell membrane permeability for release of produced molecules [7]. An alternative proposed method is the use of nanoparticles for recovery of metabolites in plant cell cultures [8]. Understanding the interaction of nanoparticle systems with plant metabolites is a crucial first step in designing nano-particle based metabolite scavenging systems.