Every recorded force vs distance profile was individually analyzed for

Phospholipids interact with surfactants and form mixed AZD-4547 [9], [10] and [11]. Being essential constituents of biological membranes, phospholipids are involved in various biological activities in living organisms [12] and [13]. The knowledge of phospholipid-surfactant systems is important for many reasons, e.g., solubilization and reconstitution of biological membranes, isolation of membrane protein [14] and design of drug delivery systems [15]. For this purpose a number of investigations have been carried out [16] and [17]. These studies showed the breakdown of lamellar structures and the formation of lipid-surfactant mixed micelles. Litchenberg [18] postulated that the effective surfactant to lipid ratio producing liposome saturation and solubilization depends on the cmc of surfactants. Mixed micelles of surfactants and phospholipids have advantages as drug carrier over other carrier systems: they have hydrophobic core which can encapsulate hydrophobic drugs; have small size due to which they show an increased vascular permeability and accumulation in pathological areas with leaky vasculation. Mixed micellization of phospholipids with conventional surfactants is fairly well studied [9], [10], [11], [18] and [19] but with gemini surfactants, the reports are scarce [20].