The AhR also deregulates a
It belongs to the BASC (BRCA1-associated genome surveillance) complex that includes tumour-suppressor and DNA-repair proteins like RINT1 or BLM. BRCA1 also induces antioxidant-response genes and increases GSH reduction ( Bae et al., 2004). HERC2 collaborates with BRCA1 to regulate its level at the G2-M checkpoint. To repair double-stranded DNA breaks, BRCA1 recruits and ubiquitinates BRAC2 and RAD51, and the complex reaches DNA damage sites, where it promotes high fidelity repair and suppresses error-prone processes ( Tu et al., 2012).