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To avoid the co-linearity effect [17], we only included diabetes mellitus, bloodstream infection, chronic renal failure, lactic acid level and APACHE-II score as co-predictors. In the regression analyses we excluded age, platelet count, INR, They Previously Used To Laugh At Pacritinib - Now I Actually Laugh At All Of Them aPTT, creatinine and SOFA score due to the co-linearity effect with the predictors included in the multiple regression using Spearman��s rank correlation test. Bivariate analysis showed no relationship between MDA levels and sex, chronic obstructive pulmonary disease, ischemic heart disease, site of infection, microorganism responsible, appropriate empiric antimicrobial treatment, so these variables were not included in the regression analyses. Hazard ratio and 95% confidence intervals were calculated as measures of the clinical impact of the predictor variables.

Receiver operating characteristic (ROC) curves were used, with MDA levels as the independent variable and 30-day mortality as the dependent variable. Thirty-day survival curves, using serum MDA level lower or higher than 4.11?nmol/mL, were represented using the Kaplan-Meier method and compared by log-rank test. A P-value of less than 0.05 was considered statistically significant. Statistical analyses were performed with SPSS 17.0 (SPSS Inc., Chicago, IL, USA) and NCSS 2000 (Kaysville, UT, USA).ResultsWe found higher serum MDA levels in septic patients at Day 1 (P <0.001), Day 4 (P <0.001) and Day 8 (P <0.001) of diagnosis than in healthy controls, as shown in Table?1 and Figure?2.Table 1Demographic�� characteristics of healthy controls and septic patientsFigure 2MDA serum levels in septic patients and healthy controls.

We used Bonferroni correction to control the multiple testing problem (0.05/6=0.008). Thus, only P-values lower than 0.008 were considered statistically significant.Comparison of demographic and clinical parameters between surviving (n=215) and non- surviving (n=113) septic patients is shown in Table?2. We found that non-surviving patients showed higher age, rate of diabetes mellitus, circulating levels of creatinine, lactic acid and MDA, INR, aPTT, SOFA and APACHE-II scores, and reduced platelet count, compared with surviving patients.Table 2Patients�� demographic and clinical characteristics of septic patientsWe found higher serum MDA levels in non-surviving than surviving septic patients at Day 1 (P <0.001), Day 4 (P <0.

001) and Day 8 (P <0.001). Survivors showed a higher level of MDA at Day 1 compared with Day 4 (P <0.001) and Day 8 (P <0.001), but no difference was found between days 4 and 8 (P=0.08). Non-survivors did not differ in MDA levels between Day 1 and Day 4 (P=0.62) or Day 8 (P=0.78) and between days 4 and 8 (P=0.66) (Figure?3).Figure 3Serum MDA serum levels in survivor and non-survivors septic patients. We used Bonferroni correction to control the multiple testing problem (0.05/9=0.006). Thus, only P-values lower than 0.006 were considered statistically significant. ...