Hot Melt Granulation in a Twin Screw Extruder Effects of Processing on Formulations with Caffeine and Ibuprofen

Hot-melt granulation (HMG) by twin screw extrusion is certainly a good novel technology for the continuous processing of pharmaceuticals but assurance must be gained regarding whether the environment affects drug properties. In this preliminary analysis, granulation was studied for a unit product comprising lactose monohydrate and substances of differing drinking water solubility, namely ibuprofen versus caffeine. The formulations had been granulated at 220 rpm and 100