# A patient with novel mutations causing MEN1 and hereditary multiple osteochondroma

This cross-sectional study complied with the Calcitriol suggestions of the Declaration of Helsinki and was approved by the Medical Ethics Committee of Chang Gung Memorial Healthcare facility, a Calcitriol health-related centre in the northern portion of Taiwan. Large ranges of SO2, NO2, CO, ozone O3, and particulate matter (PM) with an aerodynamic diameter of <10 Î¼m and <2.5 Î¼m (PM10 and PM2.5, respectively) were defined as greater than or equal to the median value of SO2 (4.4 ppb), NO2 (20.1 ppb), CO (0.53 ppm), O3 (28.7 ppb), PM10 (49.1 Î¼g/m3), and PM2.5 (29.69 Î¼g/m3). Anuria was defined as a 24-hour urine volume <50 cm3. HPT was defined as an intact PTH (iPTH) level â¥180 pg/dL.7 Hypoalbuminemia was defined as albumin <3.8 g/dL.8

Air-quality status and analysis

As a result, we calculated the average of approximately 8,760 (24Ã365) pieces of data for every monitoring station to determine the 1-year average level of air pollutants in this study.

Statistical analysis

The KolmogorovâSmirnov test was used to test if variables were normally distributed. A P-value>.05 was needed to presume a regular distribution. Information are expressed in terms of medians and interquartile selection in nonnormal distribution variables and as means Â± normal deviation in standard distribution variables. Comparisons amongst groups had been carried out using the MannâWhitney examination and Studentâs t-take a look at. The frequency of categorical variables is expressed as quantities of individuals. The Ï2 or Fisherâs exact tests have been used to analyze the correlation in between categorical variables. To compute the relative correlation of HPT (iPTH â¥180 pg/dL), odds ratios (ORs) and 95% self-confidence intervals (CIs) were attained utilizing binary logistic regression types. Logarithmic conversion was manufactured for iPTH, nPNA, higher-sensitivity (hs)-CRP, and aluminum stages. In logistic regression evaluation, univariate and forward logistic regression analysis have been used (variables with P<0.1 in the univariate regression were used in the forward method) for the association between HPT and clinical variables. The following factors were investigated: high SO2 level, high NO2 level, high CO level, high O3 level, high PM10 level, high PM2.5 level, age, PD duration, serum Cr level, logarithmic nPNA level, hypoalbuminemia, serum corrected calcium level, serum phosphate level, anuria condition, logarithmic hs-CRP level, total (renal and peritoneal) Cr clearance, use of calcitriol, use of calcium-primarily based phosphate binders, use of aluminum-based phosphate binders, logarithmic blood aluminum stage, anuria, coronary artery illness, hypertension, and substantial training amount. All the nominal variables in linear regression have been dummy coding remodeled. Lacking data had been dealt with by record-smart deletion. All statistical analyses ended up performed using SPSS model twelve. for Windows (SPSS Inc, Chicago, IL, United states of america). A P-benefit <0.05 was considered statistically significant.

A total of 141 patients without DM from a single PD center were enrolled in this study. Table 1 lists the characteristics of the study subjects (mean age 50 years). Of the patients, 111 were women, and their mean duration of PD was 67.3 months.