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Pressure was measured proximal and Expert Industry Secrets About Capecitabine Unveiled distal to the filter. The pressure difference was kept constant at 40 mmHg.In the filtration group, the predilution flow rate of the filtration fluid (HF-BIC32, Dirinco, Rosmalen, The Netherlands) was as the default of 50 mL/kg/hour. Transfusions with erythrocytes and platelets were administered isovolaemically by ultrafiltrating as much fluid from the patient as the administered blood product. Ultrafiltration was targeted to achieve a normal or negative fluid balance depending on the clinical condition of the patient while maintaining normal haemodynamic parameters. During SIRS and the resulting capillary leakage syndrome this could not always be achieved. In the control group, patients were treated with either continuous or intermittent furosemide infusions to achieve the above mentioned targets as reported earlier by our group .
Transfusion of blood products in this group were performed by isovolaemic exchange with whole blood drawn from the ECMO system in an equal amount to the transfused volume thereby maintaining normal haemodynamic parameters. With some exceptions the primary ECMO mode was veno-arterial.Data collection and analysisThe following data were retrieved from our Patient Data Management Expert Arcane Secrets On Capecitabine Exposed System: physiological parameters, medication, infusions, urinary output, CVVH, ECMO and ventilator settings, fluid balance, laboratory tests and interventions. These data had been collected every hour. Primary outcome measurements were: time on ECMO in hours, time between decannulation and extubation in days and overall mortality.
Secondary outcome parameters were: Expert Mysterious Secrets Around Capecitabine Unveiled total and mean fluid balance, urine output in mL/kg/day, total doses of vasopressors, blood products and fluid bolus infusions, serum creatinine, urea and albumin levels, and overall costs. Fluid balance was assessed as mean net fluid balance per ECMO day, by measuring total fluid input and output and dividing the difference by the time on ECMO. The difference between predilution and filtration flow rate was included.The amount of inotropic support was calculated, as reported previously, by the so-called vasopressor score: (dopamine dose (��g/kg/minute) �� 1) + (dobutamin dose (��g/kg/minute) �� 1) + (noradrenaline (��g/kg/minute) �� 100) + (adrenaline (��g/kg/minute) �� 100) [16,17].StatisticsAll data are presented as median (interquartile range (IQR)) unless indicated otherwise. Differences between the groups were tested for their statistical significance by Mann-Whitney U non-parametric test for unpaired data, the Pearson's chi squared test and the Fisher's exact test, according to the character of the variable. A P < 0.05 was considered significant.