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Fisher exact test was used for comparison, and p < 0.05 was taken as statistically significant. Results One hundred twenty-six patients underwent maxillectomy during the study period. Combined modality treatment with surgery followed by radiotherapy with or with or out chemotherapy was performed. Thirty-nine patients had total maxillectomy AZD5363 Akt inhibitor including orbital floor removal. Table 1 shows the details of the pathology, indications of surgery (whether primary or salvage), types of maxillectomy, and flaps used. Table 1 Tumor pathology, indications, flaps for total maxillectomy (n = 34) Brown's classification1 was utilized to type the defects after resection. All patients in this study had class III defects. Free flaps were used for reconstruction of the defects, to achieve oroantral or oronasal separation and to support the orbital contents.

In the 39 patients who had complete maxillectomy including orbital floor elimination, 34 underwent absolutely free tissue reconstruction with the orbital floor as well as remaining 5 had regional flap reconstruction. Twenty-six patients underwent bony reconstruction and eight individuals had only a soft tissue Ascomycin reconstruction. Sufferers with soft tissue reconstruction had some remnant posterior floor of your orbit after resection. No cost fibula flap (FFF) was utilized in 14 sufferers, tensor fascia lata (TFL) with iliac crest (IC) was used in 9 individuals, one patient underwent reconstruction with radial artery forearm absolutely free flap with bone, and one patient had totally free latissimus dorsi with rib. Fig. 1A, B, C, D exhibits the maxillectomy defect as well as the reconstructed end result inside a patient where FFF was used.

Fig. 2A, B, C, D shows the reconstructive final result of a patient who underwent maxillectomy and reconstruction with TFL-IC flap. Eight patients had a soft tissue reconstruction. Rectus abdominis totally free flap was used in six. The fascia from the flap was applied as a sling for that orbital contents. Fig. 3A, B displays the reconstructive outcome in patient in whom rectus abdominis Src inhibitor mechanism flap was utilized. Radial artery forearm absolutely free flap with out bone was used in two. A Prolene mesh shaped and connected like a sling was applied for the orbital assistance in these two instances. Table two provides facts of flap reconstruction. Table two Defect classification as well as the flap used (n = 34) Figure 1 (A) Intraoperative photograph showing total maxillectomy defect with orbital contents preserved. (B) Final result at 2 years' follow-up inside a patient reconstructed with totally free fibula osteocutaneous flap, frontal see. (C) Reconstructed end result, lateral view. ... Figure 2 (A) Final result at two years' follow-up within a patient reconstructed with, tensor fascia lata with iliac crest no cost flap, frontal view. (B) Reconstructed end result, lateral see.