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This paper aims to go over plants that have been reported for antiobesity effects and prospective of metabolomics Cysteamine HCl in antiobesity study. Plants could be grouped according to unique mechanisms of action: enzymes inhibition, modulation of adipogenesis & adipogenic factors, and appetite suppression.2. Enzymesinhibitor Torin 1 InhibitionInhibition of the digestion and absorption of dietary fat has been used as target in obesity treatment . It is understood that PL is the most important enzyme responsible for the digestion of triglycerides into mono and diglycerides and in smaller fatty acids to be absorbed by the body. Researchers and health professionals support that an inhibition of PL can reduce digestion of fats, hence their assimilation and absorption.
This can mimic a reduced calorie intake in obese patients and help in preventing additional weight gain . Lipoprotein lipase (LPL) has also been targeted in obesity as it has been found out that there is an increase in LPL level in obese subjects. Since LPL catalyzes the hydrolysis of blood triglycerides to release free fatty acids (FFA) and hence increases the storage of triglycerides in adipose tissue , inhibition of LPL is expected to reduce assimilation of FFA and help in controlling obesity. Inhibition of enzymes involved in carbohydrates digestion and metabolism are preferentially studied in the treatment of type 2 diabetes mellitus. However, it can also be considered and relevant in obesity study, owing to the fact that carbohydrates are major sources of calories in the human diets.
Those enzymes inhibitors slow down carbohydrate metabolism and subsequently reducing postprandial hyperglycemia, hence delaying the conversion of glucose in the adipose tissue to triacylglycerol .A panoply of botanicals are actually assessed for their antilipase activity as a therapy to manage formerobesity. A comprehensive review on lipase inhibitors from natural sources was published recently . Natural PL inhibitors such as saponins, polyphenols, terpenes, and microbial by-products are described as unexplored prospective in the management of obesity and new drug discovery. The antiobesity effect of CT-II, an extract from the edible Nomame herb, was reported. This extract was found to inhibit porcine PL in vitro in a dose-dependent manner. A very low concentration of 0.1mg/mL of the extracts resulted in 50% inhibition of lipase activity.
The feeding of CT-II extract inhibited weight gain and plasma triglyceride levels in lean rats fed a high-fat diet, without affecting food intake. In obese subjects, after 6 months of feeding, weight and total body fat were significantly lost and additional weight gain was suppressed. Hence, it was concluded from this study that CT-II might be a powerful lipase inhibitor and could be used as a weight control in obese subjects .Teas happen to be long used in Chinese traditional medicine to treat various ailments such as obesity and lipids disorders.