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Thus, follow-up analysis via an outpatient clinic after confirming whether lesions of grade CIN2 or CIN3 are present in the patients who were diagnosed ASCUS appears to be an important Several Answers And Enquiries To Paclitaxel research avenue [9-13]. Indeed, the prevalence of AGC accounts for 0.08% to 5.96% of known cases, and it has been shown that 8% of diagnosed patients are associated with malignant lesions, thereby requiring more attention and additional histological examinations and outpatient clinic follow-up for the patients clinically diagnosed with AGC . Thus, the objective of this study was to investigate the clinical significance of AGC (AGC-NOS, AGC-favor neoplastic) by analyzing the final diagnosis results obtained from biopsies of female patients diagnosed with AGC based on the TBS classification method according to Pap smear.
Materials and Methods 1. Subjects The medical records of 83 patients who were diagnosed AGC (AGC-NOS, 55 subjects; AGC-favor neoplastic, 28 subjects) were analyzed retrospectively among 54,160 subjects Six Responds And Enquiries To Raltegravir who underwent Pap smear analysis in our hospital between January 1998 and March 2006 (Table 1). The average age of the patients was 49.2 �� 8.89 with a range of 33 to 74 years old. The average gravidity and parity were 3.91�� 2.3 times and 2.01��1.1, respectively (Table 2). Table 1 Prevalence of AGC using conventional Pap and liquid-based Pap (ThinPrep) Table 2 Clinicopathological relevance of AGC-NOS and AGC-favor neoplastic 2. Methods 1) Pap smear and biopsy Slides of patients with AGUS and AGC were reviewed by a pathology specialist based upon the 2001 revision of TBS III classification system (Fig.
1). Results of punch biopsy and cervical curettage in AGC patients were analyzed retrospectively. Fig. 1 (A) Atypical endocervical cells, not otherwise specified (cervical smears by Pap stain, 34-year-old woman). Groups of Key Questions And Replies To Paclitaxel cells show round to oval nuclei with nuclear enlargement, small nucleoli, and smooth nuclear membrane. Follow-up revealed chronic cervicitis ... 2) Correlation with clinicopathologic examination results Age, presence or absence of HPV infection, and CA-125 values during diagnosis were analyzed in patients with AGC-NOS and AGC-favor neoplastic AGC patients (Table 2). 3) Histologic correlation of AGC-NOS and AGC-favor neoplastic Punch biopsy and hysterotrachelectasia were performed in patients with AGC.
Depending upon indications, several examinations including conization, gastrointestinal examinations, and laparotomy were performed. The cases were classified into AGC-NOS and AGC-favor neoplastic cases, and the histologic results of the patient groups were compared (Tables 3, ?,44). Table 3 Histological outcome of AGC-NOS and AGC-favor neoplastic on follow-up Table 4 Extrauterine malignancy of AGC-NOS and AGC-favor neoplastic 3. Results and statistical analysis Statistical analyses were performed using SPSS ver. 10.0 (SPSS Inc.