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8%), p-tyrosol [37�C42]; (3) flavonoids��including rodiolin, rodionin, rodiosin, acetylrodalgin, tricin [32, 34, 43], and tannins 16�C18% [44]; (4) monoterpenes, including rosiridol and rosidarin; (5) triterpenes, Lenalidomide (CC-5013) such as daucosterol and betasitosterol; (6) phenolic acids this kind of as chlorogenic, hydroxycinnamic, gallic acids [29] and crucial oils [35, 45, 46]. Each one of these substances figure out the specificity on the Rhodiola extracts. Even so, the roots have many other substances like phenolic antioxidant, which includes proanthocyanidins, quercetin, gallic acid, and chlorogenic acid [23, 47].Rosavins (rosavin, rosarin, and rosin) as well as salidroside or rhodioloside, as well as rodiolin, rodonizid, and roziridine will be the most important, and are mostly made use of as lively substances for production of healthcare preparations.

Tyrosol is also a important active ingredient; although to a significantly less extent than the other two standards. The rosavins complicated is distinct for Rhodiola rosea not like salidroside which presents in other Rhodiola species and in some plants from other genera [29, 48].Among the list of big effects in the analysis may be the detection of differences within the content material of biologically energetic substances from the roots of Rh. rosea dependent on their habitats [40, 42, 48, 49]. Investigation of rose root from diverse Bulgarian mountains areas indicated the highest quantity of salidroside of 1.55% in Rila mountain websites, and, respectively, the lowest of 0.72% in Pirin Mountain web pages [50]. The stem along with the leaves incorporate significantly less salidroside, even though there is absolutely no considerable difference while in the amounts of polyphenols accumulation while in the epigeous parts with the plant.

2.1. Taxonomy and MorphologyRhodiola rosea L. (Sedum roseum (L.) Scop., S. rhodiola DC.), rose root, golden root (Crassulaceae family members) is really a species, precious for your planet gene fund of herbs (medicinal plants) distinguished amongst another 200 species of Rhodiola genus and esteemed for its outstanding pharmacological value and use.Rhodiola meantime rosea L. is often a succulent herbaceous, perennial, and dioecious plant (obtaining separate male or female plants) which has a thick pretty branched scaly rhizome (rootstock) with typical fat of 70�C400g, but reaching 3.5kg, too. Root and rhizomes have rose scent. Several shoots grow from the identical thick root. The stem is straight, 10�C30cm in height [51]. The leaves are oblong, elliptic-oblanceolate, or obovate, total. Inflorescences are corymbiform or capitates, the flowers unisexual, flowers are set from April to August. Propagation is vegetative or by seeds [52].