Theories Of Carcinogenesis Pdf Download
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Cancer Res. Prehn RT. 2004:1097107. Nat Rev Cancer. Theories of carcinogenesisThe somatic mutation theory (SMT) has been the prevailing one in cancer research for the last 50 years . When planning experiments, researchers implicitly or explicitly decide which premises to choose.
Jacob F. Cancer Res. Regulation of cell proliferation: the negative control perspective. Thus, when reducing cancer to a cellular phenomenon, neoplasms become de facto reduced to a single transformed cell and carcinogenesis becomes equivalent to enhanced proliferation of cells in a dish. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.
Crowe SE. In a recent revisiting of the subject, we became aware that at the end of the 19th century, the famed pathologist H. The TOFT, instead, focuses on a “society of cells” and views cancer as a problem of tissue organization . Lessons from hereditary colorectal cancer. [PubMed]2. somatic mutations, is criticized but not dismissed . But, as Prehn remarked, “it may be more correct to say that cancers beget mutations than it is to say that mutations beget cancers.” . However, if oncogenes were indeed dominant determinants, as originally claimed, the need for additional gain-of-function effects attributed to these mutated genes would appear as redundant and difficult to rationalize . 2005:328. 2007:10516.
Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Englewood Clifts NJ: Prentice Hall; 1974. 2004:1495502. Estrogen mitogenic action. Proc Nat Acad Sci USA. 14. Cold Spring Harbor Symposia.