Robert Langdon awakens in a hospital room in Florence, Italy, with no memory as to what has transpired over the last few days. He suddenly finds himself, again, the target of a major manhunt. But with the help of Dr. Sienna Brooks, and his knowledge of symbology, Langdon will try to regain his freedom, and lost memories, all whilst solving the most intricate riddle he’s ever faced.
On July 16, 2013, Sony Pictures Entertainment set Ron Howard to direct Dan Brown’s fourth novel in the Robert Langdon series, Inferno, with David Koepp writing the script. Imagine Entertainment was set to produce the film, while Tom Hanks was again set to reprise his role as Robert Langdon. On August 26, 2014, Sony had finalized the deal with Howard and Hanks, and set the film for April start of production in Italy. Brian Grazer was also set to produce the film with Howard.
On December 2, Felicity Jones was in early talks to join the film. On February 17, 2015, studio revealed the confirmed cast for the film, including Jones as Dr. Sienna Brooks, Omar Sy as Christoph Bruder, Irrfan Khan as Harry “The Provost” Sims, and Sidse Babett Knudsen as Elizabeth Sinskey, head of the World Health Organization. Ben Foster was set for an unspecified villainous role on March 10, 2015.